What is an example of systemic pesticide effects based on absorption?

Systemic pesticide effects occur when a substance is absorbed into the bloodstream and affects the entire organism, rather than just the site of contact. Multi-organ failure is a severe and indicative outcome of systemic effects because it demonstrates that the pesticide has penetrated the body and is impacting multiple systems and organs simultaneously.

When a pesticide enters the bloodstream, it can be distributed throughout the body, leading to widespread toxicity that affects organs such as the liver, kidneys, and heart. This is different from reactions such as skin irritation, respiratory distress, or localized rashes, which are typically linked to direct exposure and do not involve systemic absorption. Consequently, multi-organ failure signifies a serious systemic reaction where the pesticide has impacted the body's overall physiological function due to its absorption and distribution.